Dicarboxylic acids and derivatives
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-50mg
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 g·mol⁻1 | C29H58NO8P | 50 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine lipid with lauric (12:0) acyl chains. It is commonly used as a lipid component for preparing liposomes and for studies of membrane composition in biochemical and biophysical research.
- High purity suitable for research applications.
- Useful for liposome synthesis and membrane composition studies.
- Available in multiple small pack sizes for laboratory use.
- Contains lauric (12:0) acyl chains for defined lipid composition.
- Molecular weight 579.75 g·mol⁻1 and formula C29H58NO8P for accurate formulation.
Medchemexpress LLC Ji-101 | 900573-88-8 | MFCD26142530 | 99.8% | 466.33 | C22H20BrN5O2 | 10 MG
JI-101 is an orally available multi-kinase inhibitor that targets VEGFR2, PDGFRβ, and EphB4 and has demonstrated potent anti-cancer activity. It is provided as a white to off-white solid powder for research use and is commonly supplied in a 10 mg pack.
- Orally available multi-kinase inhibitor active against VEGFR2, PDGFRβ, and EphB4.
- High purity (99.78%).
- Molecular formula C22H20BrN5O2; molecular weight 466.33 g/mol.
- White to off-white solid, soluble in DMSO at ≥ 100 mg/mL.
- Intended for research use only; not for human administration.
TARGETMOL CHEMICALS INC GLYH-101 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. purity: 98%
Medchemexpress LLC AVN-101 hydrochlorid 10mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 10 MG
AVN-101 hydrochloride is the hydrochloride salt of AVN-101, a brain-penetrant, orally active antagonist of serotonin 5-HT7 receptors used in preclinical CNS research. It is supplied as a high-purity solid for in vitro and in vivo studies.
- Potent 5-HT7 receptor antagonist with additional activity at 5-HT6, 5-HT2A, 5-HT2C, H1, and α2 adrenergic receptors.
- Brain-penetrant and orally active, suitable for CNS pharmacology studies.
- High purity solid (LCMS purity 99.59%) for reliable experimental results.
- Chemical identity: 1H-pyrido[4,3-b]indole hydrochloride; formula C21H25ClN2; Mw 340.89.
- Recommended storage: sealed at -20°C; solvent storage guidance available from supplier.
Medchemexpress LLC FITC-labeled ODN 1018 sodium | 98.7% | 8,171.00 Da | 10 MG
FITC-labeled ODN 1018 sodium is an FITC-conjugated CpG oligodeoxynucleotide that functions as a Toll-like receptor 9 (TLR9) agonist. Supplied as the sodium salt, it is used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy or flow cytometry. For research use only.
- FITC label with excitation 495 nm and emission 520 nm.
- CpG oligodeoxynucleotide sequence: d(P-thio)(T-G-A-C-T-G-T-G-A-A-C-G-T-T-C-G-A-G-A-T-G-A).
- Molecular weight approximately 8,171 Da.
- Purity 98.7% as supplied.
- Sodium salt form.
- Available in 1 mg, 5 mg, and 10 mg sizes; larger sizes available by quote.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | 574.66 | C28H35FN4O6S | 10 MG
VH 101, acid is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand developed for PROTAC research and conjugation chemistry. The molecule includes an E3 ligase recognition motif and an alkyl linker terminating in a primary amine, facilitating attachment to target protein ligands.
- Designed for use as a VHL E3 ligase ligand in PROTAC development.
- Alkyl linker with terminal amine enables straightforward conjugation chemistry.
- High reported purity suitable for research applications.
- Supplied in small research-scale quantities for synthetic work and assay testing.
Apexbio Technology LLC GlyH-101 328541-79-3 10mg
GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 g·mol⁻¹ | C29H58NO8P | 100 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) is a phosphatidylethanolamine derivative bearing two lauroyl (C12:0) acyl chains. It is a research-grade lipid commonly used for liposome formulation and membrane model studies; typical properties include a molecular weight of 579.75 g·mol⁻¹ and high purity (98.0%).
- Phosphatidylethanolamine lipid with two lauroyl (C12:0) chains.
- Suitable for liposome synthesis and membrane model studies.
- High purity (98.0%) for research applications.
- Molecular formula C29H58NO8P and molecular weight 579.75 g·mol⁻¹.
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.1% | 5 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment with excitation/emission at 411 nm/512 nm. It exhibits solid-state fluorescence and is available as a commercial colorant. This product is for research use only and not sold to patients.
- Yellow bis-azomethine pigment
- Exhibits solid-state fluorescence
- Excitation/emission: 411 nm/512 nm
- Available as a commercial colorant
TARGETMOL CHEMICALS INC PKUMDL-LC-101-D04 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4) a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 uM in a cell-free assay and at a concentration of 61 uM in wild-type but not Gpx4-/- mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 uM) reduced cholesterol peroxide-induced MEF death. purity: 98%
Medchemexpress LLC Lauroyl-L-carnitine chloride | 6919-91-1 | MFCD00274131 | 98.1% | C19H38ClNO4 | 10MG
Lauroyl-L-carnitine chloride is an orally active absorption enhancer used in research to improve the oral bioavailability of peptide compounds. Supplied as a white to off-white solid with high purity, it is applied in formulation and permeability studies to assess and enhance intestinal uptake of peptide drugs.
- Orally active absorption enhancer for peptide compounds.
- Reported to improve oral bioavailability of peptides.
- White to off-white solid suitable for formulation research.
- High purity (~98.1%) as supplied.
- Supports studies of intestinal permeability and delivery.
- Store sealed at 4°C; in solvent, -80°C (6 months) or -20°C (1 month).
![Medchemexpress LLC O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000229462.png-250.jpg)
Medchemexpress LLC O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 5 MG
UK-101 is a selective immunoproteasome β1i (LMP2) inhibitor for laboratory research. It shows reported potency with an IC50 of about 104 nM and is supplied as a high-purity solid suitable for in vitro studies; recommended solvent is DMSO.
- Selective immunoproteasome β1i (LMP2) inhibitor with IC50 ≈104 nM.
- High purity (≈99.6%).
- Available in small research quantities, e.g., 5 mg.
- Recommended solvent: DMSO for dissolution.
- Powder storage: -20°C (3 years) or 4°C (2 years); solutions: -80°C (6 months).
- For research use only; not for human or clinical use.
Medchemexpress LLC Phenylmethyl ester | 831217-40-4 | UPCMLD00WMAL3-101 | 98.2% | 931.12 g/mol | C54H66N4O10 | 25MG
MAL3-101 is a small-molecule allosteric inhibitor of HSP70 used in biochemical and cellular research to modulate HSP70 ATPase activity and disrupt Hsp40 co-chaperone interactions. It is a membrane-permeable dihydropyrimidine analog supplied as a solid powder for laboratory use.
- Allosteric inhibitor of HSP70 ATPase activity.
- Disrupts Hsp40 co-chaperone interaction.
- Demonstrated activity in cellular antiproliferative studies.
- High purity suitable for research (>98%).
- Powder form with DMSO solubility for assay preparation.
- Recommended storage: powder at -20°C; in solvent at -80°C for longer storage.
Selleck Chemical LLC CUDC-101 S1194-10mM/1mL
CUDC-101 is a potent multi-targeted inhibitor against HDAC EGFR and HER2 with IC50 of 4 4 nM 2 4 nM and 15 7 nM and inhibits class I/II HDACs but not class III Sir-type HDACs Phase 1