Dicarboxylic acids and derivatives
![Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247159.png-250.jpg)
Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG
CUDC-101 is a small-molecule research compound that concurrently inhibits histone deacetylases (HDACs) and receptor tyrosine kinases EGFR and HER2. It is used in preclinical cancer research to study combined epigenetic and kinase-targeted therapies.
- Potent inhibition of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM.
- Contains a hydroxamic acid moiety associated with HDAC activity.
- High purity (>98.0%) suitable for research applications.
- Soluble in DMSO at 25 mg/mL (approximately 57.54 mM; may require ultrasonic agitation).
- Molecular formula C24H26N4O4 and molecular weight 434.49 g/mol.
Selleck Chemical LLC NLX-101 S3510-5mg
NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 10mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Medchemexpress LLC PKUMDL-LC-101-D04 50mg | 2143896-83-5 | 378.94 g·mol⁻¹ | C14H23ClN4O2S2 | 50 MG
Small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used as a research tool to study ferroptosis and inflammation. Reported activity includes an approximate pEC50 of 4.7 and an ability to increase GPX4 activity in biochemical assays. Supplied as a solid with good solubility in DMSO for assay preparation.
- Allosteric activation of glutathione peroxidase 4 with reported pEC50 ≈ 4.7.
- Shown to increase GPX4 activity to about 150% in biochemical assays.
- Useful for probing ferroptosis and inflammation pathways in preclinical research.
- Supplied as a solid with high DMSO solubility for convenient dilution and assay use.
- Vendor-reported molecular formula and molecular weight provided for analytical reference.
![Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | 386.42 g/mol | C22H19FN6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | 386.42 g/mol | C22H19FN6 | 5 MG
KYN-101 is a potent, selective, orally active aryl hydrocarbon receptor (AHR) inhibitor used in research. It reduces CYP1A1 mRNA expression and has demonstrated anti-cancer activity in preclinical studies. Supplied as a small-quantity research compound with accompanying quality documentation.
- Potent, selective aryl hydrocarbon receptor (AHR) inhibitor.
- Orally active in preclinical models.
- Decreases CYP1A1 mRNA expression in cellular assays.
- Demonstrates anti-cancer activity in preclinical studies.
- Supplied as a small research quantity (e.g., 5 mg) with COA and datasheet.
- High purity (approximately 98.0%).
- For research use only; not for human or clinical use.
Medchemexpress LLC BNC-101 5mg | 5mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
Apexbio Technology LLC AS 101 106566-58-9 50mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies
Medchemexpress LLC Rhodamine 101 chloride | 64339-18-0 | 527.05 g/mol | C32H31ClN2O3 | 10 MG
Rhodamine 101 chloride is a bright xanthene-class fluorescent dye with excitation and emission maxima at 565 nm and 595 nm, respectively. It is used for fluorescence microscopy, cellular staining, and as a red-spectrum reference standard. The solid is supplied in small laboratory pack sizes and should be stored protected from light and moisture; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Excitation 565 nm and emission 595 nm.
- Suitable for fluorescence microscopy and cellular staining.
- Useful as a reference standard in red-spectrum labeling.
- Available in small lab pack sizes, including 10 mg.
- Store sealed, protected from moisture and light.
Apexbio Technology LLC GlyH-101 328541-79-3 50mg
GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
Medchemexpress LLC RG-101 sodium | 00-00-0 | 95.4% | 8537.6 (free acid) | C295H410N78Na19O146P19S17 | 5 MG
RG-101 sodium is a hepatocyte-targeted N-acetylgalactosamine (GalNAc)-conjugated antisense oligonucleotide that antagonizes microRNA-122 (miR-122), a host factor important for hepatitis C virus replication. Supplied as a sodium salt, it is used in research to study miR-122 biology and antiviral mechanisms.
- Hepatocyte-targeted GalNAc conjugate for liver delivery.
- Antagonizes miR-122 to modulate hepatitis C virus-related pathways.
- High molecular weight oligonucleotide for sequence-specific activity.
- High purity (95.4%) suitable for research applications.
- Soluble in water; sonication may be required for dissolution.
- Recommended storage at -20°C; in solution store at -80°C for long-term.
TARGETMOL CHEMICALS INC MG-101 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. purity: 98%
Medchemexpress LLC Ethyl Lauroyl Argina 5g
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative[1]
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 1mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
![Medchemexpress LLC Tetradecanoic acid, 2,3-bis[(1-oxododecyl)oxy]propyl ester | 60175-30-6 | MFCD00063570 | 98.0% | 667.05 g/mol | C41H78O6 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000288249.png-250.jpg)
Medchemexpress LLC Tetradecanoic acid, 2,3-bis[(1-oxododecyl)oxy]propyl ester | 60175-30-6 | MFCD00063570 | 98.0% | 667.05 g/mol | C41H78O6 | 10 MG
1,2-Dilauroyl-3-myristoyl-rac-glycerol is a medium-chain triacylglycerol used as a research reagent and an intermediate for synthesizing functional edible oils and related lipid derivatives. It is typically supplied in small, research-scale quantities for laboratory studies.
- Medium-chain triacylglycerol suitable for lipid synthesis and formulation.
- High purity (98.0%) suitable for research applications.
- Chemical formula C41H78O6; molecular weight 667.05 g/mol.
- Appearance: white to off-white oil.
- Provided in small research-scale quantities (e.g., 10 mg).